How a protein called MxB helps fight herpesviruses
Evolution and mechanism of restriction of herpesviruses by MxB
This study is looking at a protein called MxB that helps our bodies fight off herpes viruses, like the ones that cause cold sores and genital herpes, to see how it works and how it has changed in humans compared to other primates, which could help us understand better ways to boost our immune system against these infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10911144 on NIH RePORTER |
What this research studies
This research investigates the role of the myxovirus resistance protein B (MxB) in restricting herpesviruses, particularly herpes simplex virus types 1 and 2. The study aims to understand how MxB has evolved in humans compared to non-human primates and how it effectively inhibits these viruses. By examining the specific genetic features of MxB and its interactions with viral factors, researchers hope to uncover the mechanisms behind its antiviral properties. This could lead to new insights into how our immune system combats herpesvirus infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with herpes simplex virus types 1 or 2.
Not a fit: Patients who do not have herpesvirus infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments or preventive strategies against herpesvirus infections.
How similar studies have performed: Previous research has shown that understanding host-virus interactions can lead to significant advancements in antiviral therapies, suggesting potential success for this approach.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Geballe, Adam P. — Fred Hutchinson Cancer Center
- Study coordinator: Geballe, Adam P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.