How a protein called MxB helps fight herpesviruses
Official title: Evolution and mechanism of restriction of herpesviruses by MxB
Funded at Fred Hutchinson Cancer Center · NIH-10911144 · Data updated 2026-11-12
This study is looking at a protein called MxB that helps our bodies fight off herpes viruses, like the ones that cause cold sores and genital herpes, to see how it works and how it has changed in humans compared to other primates, which could help us understand better ways to boost our immune system against these infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 21, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $220,000 |
| NIH project number | 5R21AI171353-02 |
| Project ID | NIH-10911144 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals infected with herpes simplex virus types 1 or 2.
✕Less likely to help
Patients who do not have herpesvirus infections may not benefit from this research.
What this research studies
This research investigates the role of the myxovirus resistance protein B (MxB) in restricting herpesviruses, particularly herpes simplex virus types 1 and 2. The study aims to understand how MxB has evolved in humans compared to non-human primates and how it effectively inhibits these viruses. By examining the specific genetic features of MxB and its interactions with viral factors, researchers hope to uncover the mechanisms behind its antiviral properties. This could lead to new insights into how our immune system combats herpesvirus infections.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments or preventive strategies against herpesvirus infections.
How similar studies have gone: Previous research has shown that understanding host-virus interactions can lead to significant advancements in antiviral therapies, suggesting potential success for this approach.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Geballe, Adam P. — Fred Hutchinson Cancer Center
- Study coordinator: Geballe, Adam P.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.