How a protein called MED12 affects gene regulation in heart cells
Official title: Transcriptional Coordination and Gene Regulation by MED12 in the Cardiomyocyte
Funded at Ohio State University · NIH-11077268 · Data updated 2026-11-12
This study is looking at how a protein called MED12 helps control the genes that keep our heart muscle cells working properly, especially when it comes to heart disease, to better understand what goes wrong in heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $585,268 |
| NIH project number | 5R01HL166520-03 |
| Project ID | NIH-11077268 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with heart disease or those at risk of developing cardiac disorders.
✕Less likely to help
Patients with non-cardiac conditions or those without any heart disease may not benefit from this research.
What this research studies
This research investigates the role of the MED12 protein in regulating gene expression in heart muscle cells, known as cardiomyocytes. It aims to understand how MED12 interacts with other proteins to control the transcription of genes that are crucial for heart function, particularly in the context of heart disease. By examining the molecular mechanisms of MED12, the research seeks to uncover how disruptions in gene regulation contribute to heart failure. The study involves advanced techniques to analyze gene expression and protein interactions in both healthy and diseased heart tissues.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating heart disease by targeting the mechanisms of gene regulation.
How similar studies have gone: Previous research has shown promising results in understanding gene regulation in heart disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Baskin, Kedryn K — Ohio State University
- Study coordinator: Baskin, Kedryn K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.