How a protein called MDC1 helps repair DNA damage in cells
Official title: Molecular regulation of double-strand break repair by MDC1
Funded at Wayne State University · NIH-11278376 · Data updated 2026-11-12
This study is looking at how a protein called MDC1 helps fix broken DNA in our cells, which is really important for keeping our genes healthy, and it could help us find new treatments for cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | December 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 4R00GM149942-03 |
| Project ID | NIH-11278376 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic predispositions to cancer, particularly those with mutations in DNA repair genes like BRCA1.
✕Less likely to help
Patients with conditions unrelated to DNA repair mechanisms or those without genetic predispositions to cancer may not benefit from this research.
What this research studies
This research investigates the role of the MDC1 protein in repairing DNA double-strand breaks, which are critical for maintaining genomic integrity. The study focuses on understanding how MDC1 interacts with other proteins and chromatin to facilitate two main repair pathways: Homologous Recombination (HR) and Non-Homologous End Joining (NHEJ). Using advanced imaging techniques, researchers aim to uncover the mechanisms by which MDC1 promotes these repair processes, particularly its unique functions that do not rely on the well-known BRCA1 protein. This research could provide insights into how cells respond to DNA damage, which is crucial for developing new therapies for conditions like cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing DNA repair mechanisms, potentially benefiting patients with cancer by informing new treatment approaches.
How similar studies have gone: Other research has shown promising results in understanding DNA repair mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
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Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Heyza, Joshua — Wayne State University
- Study coordinator: Heyza, Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.