How a protein called IPMK helps cells move and grow
Official title: IPMK is a novel PI3k essential for mTORC2 activation and cell migration
Funded at University of Nevada Las Vegas · NIH-11140961 · Data updated 2026-11-12
This project aims to understand how a protein called IPMK helps cells move and grow, which is important for many body functions and diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Las Vegas NIH-funded |
| Lab location | 1 site (Las Vegas, United States) |
| Project start | July 18, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $187,746 |
| NIH project number | 5R16GM154726-02 |
| Project ID | NIH-11140961 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational biological work does not directly involve patient participation at this stage, but future applications could benefit individuals with conditions related to cell growth and migration.
✕Less likely to help
Patients will not receive direct medical benefit from this basic science project, as it focuses on fundamental cellular mechanisms.
What this research studies
Our bodies rely on cells moving and growing correctly, and this work looks at a key protein called IPMK that plays a role in these processes. We want to discover how IPMK helps activate another important cellular pathway, mTORC2, which is involved in cell growth and survival. We are also exploring if IPMK's activity directly affects how cells move or if it works through other pathways. Understanding these basic cellular mechanisms could help us learn more about conditions where cell movement and growth go wrong, like in cancer or wound healing.
Why it matters
Potential benefit: If successful, this foundational knowledge could lead to a better understanding of diseases involving abnormal cell growth and movement, potentially guiding the development of new treatments in the future.
How similar studies have gone: This work builds upon previous findings regarding IPMK's role in cell processes, but its specific focus on IPMK's mechanism in mTORC2 activation and cell migration is a novel area of investigation.
Where this research is happening
-
University of Nevada Las Vegas
Las Vegas, United States Active
Researchers
- Principal investigator: Guha, Prasun — University of Nevada Las Vegas
- Study coordinator: Guha, Prasun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.