How a protein called H3.3 controls immune system responses
Histone Variant H3.3 as a Transcription Rheostat in the Immune System
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11227562
This research looks at how a specific protein, H3.3, helps control how our immune cells react to infections and inflammation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11227562 on ClinicalTrials.gov |
What this research studies
Our immune system needs to respond quickly to threats like infections. We've found that a protein called H3.3 and how much of it is present plays a key role in turning on inflammatory genes in immune cells, like macrophages and B cells. This project aims to understand how different levels of H3.3 act like a dimmer switch, fine-tuning our immune responses. We are using advanced genetic models to see how changing H3.3 levels affects immune cell function and the body's ability to fight off infections.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but could inform future treatments for individuals with immune system dysregulation or severe infections.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to adjust immune responses, potentially helping patients with inflammatory conditions or severe infections.
How similar studies have performed: This research builds upon previous findings by the same team, suggesting a novel and promising approach to understanding immune regulation.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOSEFOWICZ, STEVEN ZVI — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: JOSEFOWICZ, STEVEN ZVI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.