How a protein called CD53 guides B cells in the body
Defining the partner interaction network of the tetraspanin CD53 in regulating B cell trafficking
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-11116852
We are learning how a protein called CD53 guides B cells, which are important immune cells, to their correct places in the body.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11116852 on ClinicalTrials.gov |
What this research studies
Our immune system relies on B cells to fight infections and produce antibodies. This project explores how a specific protein called CD53, found on the surface of B cells, helps them move and find their correct locations in the body. When CD53 isn't working properly, B cells may not move as they should, which can weaken the immune system. By understanding how CD53 interacts with other proteins, we hope to learn more about its role in both healthy B cells and in conditions like B-cell leukemia. This knowledge could eventually lead to new ways to support immune function or treat certain blood cancers.
Who could benefit from this research
Good fit: While this is a foundational science project, future clinical applications may benefit patients with impaired immune function or B-cell related conditions like leukemia.
Not a fit: Patients whose conditions are not related to B cell function or trafficking would likely not see direct benefits from this specific research.
Why it matters
Potential benefit: Successfully understanding CD53's role could lead to new ways to improve immune function or develop treatments for B-cell related diseases, including certain leukemias.
How similar studies have performed: Previous work has shown that CD53 is important for B cell development and movement, suggesting a strong foundation for this deeper exploration.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHUETTPELZ, LAURA G. — WASHINGTON UNIVERSITY
- Study coordinator: SCHUETTPELZ, LAURA G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.