How a protein called ANGPTL3 affects cholesterol and heart health
Official title: Regulation of Endothelial Lipase and HDL Metabolism by ANGPTL3
Funded at University of Iowa · NIH-11000818 · Data updated 2026-11-12
This study is looking at a protein called ANGPTL3 to see how it affects cholesterol and heart health, which could help us find better ways to manage heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | January 13, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $469,522 |
| NIH project number | 5R01HL162698-03 |
| Project ID | NIH-11000818 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with dysregulated lipid metabolism or those at risk for cardiovascular diseases.
✕Less likely to help
Patients with established cardiovascular disease who are not responsive to lipid-modifying therapies may not benefit from this research.
What this research studies
This research investigates the role of ANGPTL3, a protein that regulates lipid metabolism, in cardiovascular disease. It aims to understand how ANGPTL3 inhibits endothelial lipase, an enzyme involved in cholesterol processing, and how this inhibition impacts high-density lipoprotein (HDL) metabolism. By studying genetically modified mice, the researchers will explore the mechanisms by which ANGPTL3 influences cholesterol levels and contributes to atherosclerosis, a major cause of heart disease. The findings could lead to new insights into managing cardiovascular health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cholesterol management and reduce the risk of cardiovascular disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of ANGPTL proteins in lipid metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Davies, Brandon Scott Joseph — University of Iowa
- Study coordinator: Davies, Brandon Scott Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.