How a protein called adipsin helps protect insulin-producing cells in diabetes
Alternative complement pathway regulation of beta cell homeostasis
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-10530710
This study is looking at how a protein called adipsin, which is lower in people with obesity, helps keep the insulin-producing cells in the pancreas healthy, and it's specifically for those with type 2 diabetes to see if boosting adipsin can help these cells work better and stay alive longer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10530710 on ClinicalTrials.gov |
What this research studies
This research investigates the role of adipsin, a protein that is reduced in obesity, in maintaining the health of insulin-producing beta cells in the pancreas. By studying mice with type 2 diabetes, the researchers aim to understand how adipsin influences beta cell function and survival through its interaction with specific receptors. The study will explore the mechanisms by which adipsin treatment can prevent the deterioration of these cells, which is crucial for managing diabetes effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 2 diabetes, particularly those experiencing challenges with insulin production.
Not a fit: Patients with type 1 diabetes or those without any form of diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that preserve beta cell function and improve blood sugar control in patients with type 2 diabetes.
How similar studies have performed: Previous studies have shown promising results in using similar approaches to enhance beta cell survival and function, indicating potential for success in this research.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LO, JAMES C — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: LO, JAMES C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.