How a protein called ADH5 helps brown fat manage metabolism
Role of ADH5 in the Regulation of Brown Adipose Tissue Metabolic Homeostasis
This project explores how a protein called ADH5 in brown fat helps manage metabolism and inflammation in people with obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11120993 on NIH RePORTER |
What this research studies
Many people with obesity experience problems with their metabolism and ongoing inflammation in their bodies. Brown fat, a special type of fat, is important for how our bodies use energy, but its function can be disrupted in obesity, leading to more inflammation. This research aims to understand how a specific protein, ADH5, helps brown fat maintain a healthy balance and reduce inflammation. We believe that when ADH5 levels are low in brown fat, it can worsen metabolic issues and inflammation. By learning more about ADH5, we hope to find new ways to support brown fat health and improve metabolic function.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals living with obesity and related metabolic conditions.
Not a fit: Patients would not receive direct benefit from this basic science project, as it focuses on understanding fundamental biological mechanisms.
Why it matters
Potential benefit: If successful, this work could lead to new ways to improve metabolism and reduce inflammation in brown fat, potentially offering new strategies for treating obesity.
How similar studies have performed: This project builds on preliminary findings that suggest ADH5 plays a protective role in brown fat, representing a novel area of investigation.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Yang, Ling — University of Iowa
- Study coordinator: Yang, Ling
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.