How a protein affects kidney function and blood pressure regulation
Regulation of NKCC2 isoforms and blood pressure by tumor necrosis factor-alpha
This study is looking at how a substance made in the kidneys called TNF affects blood pressure, especially when you eat salty foods, using special mice to learn more about how it works and how it might help us understand high blood pressure better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Medical College NIH-funded |
| Lab location | 1 site (Valhalla, United States) |
| Project ID | NIH-11144012 on NIH RePORTER |
What this research studies
This research investigates the role of tumor necrosis factor-alpha (TNF) produced in the kidneys and its impact on blood pressure regulation, particularly in response to dietary salt intake. The study employs genetically modified mouse models to explore how TNF influences specific kidney cells and their functions. By silencing TNF production in targeted kidney regions, researchers aim to uncover the mechanisms behind TNF's effects on sodium transport and blood pressure control. This work could lead to a better understanding of hypertension and its management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with hypertension, especially those who are sensitive to dietary salt intake.
Not a fit: Patients with normal blood pressure or those not affected by dietary salt intake may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing high blood pressure, particularly in populations affected by salt sensitivity.
How similar studies have performed: Previous research has shown promising results in understanding the role of TNF in kidney function, suggesting that this approach could yield valuable insights.
Where this research is happening
Valhalla, United States
- New York Medical College — Valhalla, United States (Active)
Researchers
- Principal investigator: Ferreri, Nicholas R — New York Medical College
- Study coordinator: Ferreri, Nicholas R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.