How a protein affects kidney function and blood pressure regulation
Official title: Regulation of NKCC2 isoforms and blood pressure by tumor necrosis factor-alpha
Funded at New York Medical College · NIH-11144012 · Data updated 2026-11-12
This study is looking at how a substance made in the kidneys called TNF affects blood pressure, especially when you eat salty foods, using special mice to learn more about how it works and how it might help us understand high blood pressure better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Medical College NIH-funded |
| Lab location | 1 site (Valhalla, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $84,700 |
| NIH project number | 3R01HL153525-04S1 |
| Project ID | NIH-11144012 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with hypertension, especially those who are sensitive to dietary salt intake.
✕Less likely to help
Patients with normal blood pressure or those not affected by dietary salt intake may not benefit from this research.
What this research studies
This research investigates the role of tumor necrosis factor-alpha (TNF) produced in the kidneys and its impact on blood pressure regulation, particularly in response to dietary salt intake. The study employs genetically modified mouse models to explore how TNF influences specific kidney cells and their functions. By silencing TNF production in targeted kidney regions, researchers aim to uncover the mechanisms behind TNF's effects on sodium transport and blood pressure control. This work could lead to a better understanding of hypertension and its management.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing high blood pressure, particularly in populations affected by salt sensitivity.
How similar studies have gone: Previous research has shown promising results in understanding the role of TNF in kidney function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York Medical College
Valhalla, United States Active
Researchers
- Principal investigator: Ferreri, Nicholas R — New York Medical College
- Study coordinator: Ferreri, Nicholas R
Related research
Other NIH-funded projects on the same topics.
-
Actions to Decrease Disparities in Blood Pressure Control for Blacks
Aiming to help Black patients manage high blood pressure by using nurses, community health workers, and home monitoring in real-world clinics.
-
Cognitive behavioral therapy and trazodone for insomnia phenotypes with high blood pressure
A clinical study tests how CBT-I and the sleep drug trazodone work for adults with insomnia and high blood pressure, focusing on a specific sleep duration pattern.
-
Music-powered tools to boost blood pressure and stroke prevention for Nigerian youth and their older caregivers
This project uses popular music to help Nigerian youths and their older family members start and stick to blood pressure and stroke prevention habits.
-
Non-invasive, continuous blood pressure monitoring for prenatal maternal health
A wearable device from PyrAmes uses comfortable, non-invasive sensors and smart software to constantly monitor a pregnant person’s blood pressure and heart health so doctors can protect both mom and baby.
-
Smartphone app helps pregnant women in Ghana monitor blood pressure at home
A smartphone app is being customized for pregnant women in Ghana to support home blood pressure monitoring and improve safety during pregnancy.
-
Nap duration during night shifts and blood pressure health
A Phase II study will test how long night shift naps should be to restore normal blood pressure patterns and maintain safe performance, while considering caffeine use, for night workers.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.