How a protein affects kidney function and blood pressure regulation
Regulation of NKCC2 isoforms and blood pressure by tumor necrosis factor-alpha
['FUNDING_R01'] · NEW YORK MEDICAL COLLEGE · NIH-10908433
This study is looking at how a substance called TNF made in the kidneys affects blood pressure, especially when you eat salty foods, and it hopes to find new ways to help manage blood pressure for people who struggle with it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK MEDICAL COLLEGE (nih funded) |
| Locations | 1 site (VALHALLA, UNITED STATES) |
| Trial ID | NIH-10908433 on ClinicalTrials.gov |
What this research studies
This research investigates the role of tumor necrosis factor-alpha (TNF) produced in the kidney and its impact on blood pressure regulation, especially in response to dietary salt intake. By using genetically modified mouse models and specialized techniques to silence TNF production in specific kidney cells, the study aims to uncover the mechanisms by which TNF influences kidney function and blood pressure. The findings could lead to a better understanding of how to manage blood pressure through targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with high blood pressure, especially those of African American descent, who may benefit from improved blood pressure management strategies.
Not a fit: Patients with normal blood pressure or those not affected by kidney-related issues may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for managing high blood pressure, particularly in populations that are disproportionately affected.
How similar studies have performed: Other research has shown promising results in understanding the role of TNF in kidney function, suggesting that this approach could yield valuable insights.
Where this research is happening
VALHALLA, UNITED STATES
- NEW YORK MEDICAL COLLEGE — VALHALLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FERRERI, NICHOLAS R — NEW YORK MEDICAL COLLEGE
- Study coordinator: FERRERI, NICHOLAS R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.