How a protein affects immune cells involved in heart disease
Official title: Complement Protein C1q Regulation of Macrophage Metabolic Pathways
Funded at California State University Long Beach · NIH-11038047 · Data updated 2026-11-12
This study is looking at how a protein called C1q affects immune cells that help manage cholesterol and inflammation, which could lead to better treatments for atherosclerosis, a condition that can cause heart attacks and strokes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State University Long Beach NIH-funded |
| Lab location | 1 site (Long Beach, United States) |
| Project start | May 1, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $132,750 |
| NIH project number | 5R16GM149507-03 |
| Project ID | NIH-11038047 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for atherosclerosis, including those with high cholesterol, diabetes, or a family history of heart disease.
✕Less likely to help
Patients who do not have any risk factors for atherosclerosis or existing cardiovascular conditions may not benefit from this research.
What this research studies
This research investigates the role of complement protein C1q in regulating the metabolism of macrophages, which are immune cells that play a crucial role in the development of atherosclerosis, a condition that can lead to heart attacks and strokes. The study aims to understand how C1q influences macrophage behavior, particularly in the context of cholesterol removal and inflammation. By examining the mechanisms through which C1q operates, the research seeks to identify potential therapeutic targets for improving macrophage function and reducing plaque formation in arteries.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the ability of immune cells to clear cholesterol and reduce inflammation, potentially lowering the risk of heart disease.
How similar studies have gone: Previous research has shown that targeting immune cell functions can be effective in managing atherosclerosis, suggesting that this approach may yield promising results.
Where this research is happening
-
California State University Long Beach
Long Beach, United States Active
Researchers
- Principal investigator: Fraser, Deborah Ann — California State University Long Beach
- Study coordinator: Fraser, Deborah Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.