How a protein affects fat cell development and obesity
Official title: Regulation of adipose tissue remodeling by the CCNC-Mediator
Funded at Albert Einstein College of Medicine · NIH-11045997 · Data updated 2026-11-12
This study is looking at how a protein called Cyclin C affects fat cells and their role in obesity and type 2 diabetes, using mice to find ways to help improve health for people dealing with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $570,268 |
| NIH project number | 1R01DK139610-01A1 |
| Project ID | NIH-11045997 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are struggling with obesity or have been diagnosed with type 2 diabetes.
✕Less likely to help
Patients who are not affected by obesity or type 2 diabetes may not receive any benefit from this research.
What this research studies
This research investigates the role of a protein called Cyclin C (CCNC) in the development and function of fat cells, particularly in relation to obesity and type 2 diabetes. By using mouse models, the study aims to understand how CCNC influences the number of fat cells and their ability to function healthily. The researchers will explore the mechanisms behind fat cell remodeling and how these processes can be manipulated to improve metabolic health. This could lead to new strategies for treating obesity-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help manage or prevent obesity and type 2 diabetes by promoting healthier fat cell development.
How similar studies have gone: Previous research has shown promising results in understanding fat cell biology and its implications for metabolic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Yang, Fajun James — Albert Einstein College of Medicine
- Study coordinator: Yang, Fajun James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.