How a protein affects bone growth and inflammation in the mouth
Official title: Molecular control of bone development and inflammation by FBXO11
Funded at University of California Los Angeles · NIH-11195842 · Data updated 2026-11-12
This study is looking at a protein called FBXO11 to see how it affects bone health and inflammation in people with gum diseases like periodontitis and peri-implantitis, with the goal of finding new ways to help prevent tooth loss and improve healing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 20, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $303,445 |
| NIH project number | 7R01DE029200-06 |
| Project ID | NIH-11195842 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from periodontitis or peri-implantitis who are experiencing bone loss.
✕Less likely to help
Patients without inflammatory bone diseases or those who do not have dental implants may not benefit from this research.
What this research studies
This research investigates the role of a protein called FBXO11 in regulating bone development and inflammation, particularly in conditions like periodontitis and peri-implantitis, which are common inflammatory diseases affecting the mouth. The study aims to understand how FBXO11 influences bone formation and resorption, which can become uncoupled during chronic inflammation, leading to tooth loss and implant failure. By exploring the FBXO11 signaling pathway, the researchers hope to identify new strategies to prevent bone loss and promote healing in patients with these conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent bone loss and enhance recovery for patients suffering from inflammatory bone diseases in the oral cavity.
How similar studies have gone: While the specific role of FBXO11 in bone development and inflammation is novel, similar research has shown promise in understanding inflammatory processes affecting bone health.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Chang, Jia — University of California Los Angeles
- Study coordinator: Chang, Jia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.