How a protein affects blood vessel growth and metabolism in diabetes
Mitochondrial dynamics protein Drp1 regulation of endothelial metabolism, ROS, and ischemic vascular disease
['FUNDING_P01'] · AUGUSTA UNIVERSITY · NIH-11103156
This study is looking at how a protein called Drp1 affects the way blood vessel cells use energy, especially in people with diabetes who have trouble with blood flow, to find new ways to help improve healing and blood vessel growth.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | AUGUSTA UNIVERSITY (nih funded) |
| Locations | 1 site (AUGUSTA, UNITED STATES) |
| Trial ID | NIH-11103156 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called Drp1 in regulating the metabolism of endothelial cells, which are crucial for blood vessel formation. It focuses on how reactive oxygen species (ROS) signaling influences glycolysis in these cells, particularly in the context of diabetic peripheral arterial disease (PAD). The study aims to understand how Drp1's modifications can promote or impair the growth of new blood vessels, which is essential for healing in diabetic patients. By exploring these mechanisms, the research seeks to uncover potential therapeutic targets for improving vascular health in individuals with diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetic peripheral arterial disease who experience impaired blood flow and healing.
Not a fit: Patients without diabetes or those who do not have vascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance blood vessel growth and improve healing in diabetic patients.
How similar studies have performed: Other research has shown promising results in understanding the role of ROS in vascular health, suggesting that this approach could lead to significant advancements.
Where this research is happening
AUGUSTA, UNITED STATES
- AUGUSTA UNIVERSITY — AUGUSTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: USHIO-FUKAI, MASUKO — AUGUSTA UNIVERSITY
- Study coordinator: USHIO-FUKAI, MASUKO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.