How a parasite spreads in the body using immune cells
Mechanisms of host leukocyte-mediated Toxoplasma dissemination in its host
This study is looking at how the Toxoplasma gondii parasite spreads in people with weakened immune systems, like those with AIDS or who have had transplants, and it focuses on a special protein that helps the parasite move around in the body, which could lead to new ways to treat infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11076215 on NIH RePORTER |
What this research studies
This research investigates how the parasite Toxoplasma gondii spreads within the body, particularly in patients with weakened immune systems, such as those with AIDS or transplant recipients. The study focuses on a specific protein, TgWIP, that the parasite uses to manipulate immune cells, enabling it to move from the site of infection to critical organs like the brain. By understanding the molecular mechanisms behind this process, researchers aim to uncover potential targets for therapeutic intervention. The approach involves detailed analysis of how TgWIP interacts with host cell components to facilitate the parasite's dissemination.
Who could benefit from this research
Good fit: Ideal candidates for this research are immunosuppressed individuals, such as those with AIDS or organ transplant recipients.
Not a fit: Patients with healthy immune systems are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the spread of Toxoplasma gondii in vulnerable patients.
How similar studies have performed: Previous research has shown success in understanding similar mechanisms of pathogen dissemination, suggesting potential for breakthroughs in this area.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Saeij, Jeroen — University of California at Davis
- Study coordinator: Saeij, Jeroen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.