How a nutrient sensor affects the health and function of pancreatic beta cells in diabetes
Official title: Nutrient-sensor O-GlcNAc Transferase Regulation of Autophagy in Homeostatis of Pancreatic Beta-cell Mass and Function
Funded at University of Minnesota · NIH-10907874 · Data updated 2026-11-12
This study is looking at how a protein called OGT helps keep the insulin-producing cells in your pancreas healthy, which could lead to new ways to improve their function and help manage diabetes better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 8, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $232,500 |
| NIH project number | 1R56DK136293-01A1 |
| Project ID | NIH-10907874 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type 2 diabetes or related conditions that affect pancreatic beta cell function.
✕Less likely to help
Patients with Type 1 diabetes or those whose diabetes is not related to beta cell dysfunction may not benefit from this research.
What this research studies
This research investigates the role of O-GlcNAc transferase (OGT), a protein that senses nutrients and stress, in maintaining the health and function of pancreatic beta cells, which are crucial for insulin production. The study aims to understand how OGT interacts with other signaling pathways to regulate autophagy, a process that helps cells recycle and maintain their components. By examining these mechanisms, the research seeks to uncover potential interventions that could improve beta cell function and combat diabetes-related complications.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance pancreatic beta cell function and improve glucose regulation in diabetes patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of nutrient sensors in cellular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Alejandro, Emilyn — University of Minnesota
- Study coordinator: Alejandro, Emilyn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.