How a normal protein protects against brain diseases like Alzheimer's
Regulation of Neurodegeneration by Nonpathogenic Cellular Prion Protein and LRP1
This project explores how a natural protein in our bodies might help reduce brain inflammation in conditions like Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11196075 on NIH RePORTER |
What this research studies
Brain inflammation plays a big role in diseases like Alzheimer's, Parkinson's, and Tauopathies. We are looking into how a normal protein, called Cellular Prion Protein (PrPC), helps calm down this inflammation. Our previous work showed that PrPC, when released from cells, can block inflammatory responses in immune cells. We now have evidence that this same anti-inflammatory action happens in brain cells called microglia. We hope to learn how to use this natural protective mechanism to develop new ways to treat neurodegenerative diseases.
Who could benefit from this research
Good fit: Patients with neurodegenerative conditions such as Alzheimer's, Parkinson's, or Tauopathies could potentially benefit from future therapies developed from this fundamental understanding.
Not a fit: Patients seeking immediate treatment options will not directly benefit from this foundational laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that reduce brain inflammation and slow the progression of neurodegenerative diseases like Alzheimer's.
How similar studies have performed: Previous research in animal models has shown that this protein can reduce inflammation, and our team has identified key receptors involved in this process.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Gonias, Steven L. — University of California, San Diego
- Study coordinator: Gonias, Steven L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.