How a new form of an enzyme affects blood vessel health
Official title: Regulation of Vascular Smooth Muscle Cell Phenotype by a Novel Isoform of Glucose-6-Phosphate Dehydrogenase
Funded at New York Medical College · NIH-10983801 · Data updated 2026-11-12
This study is looking at a new form of an enzyme that helps keep your blood vessels healthy, especially for people with certain genetic traits, to see if it can help prevent problems like stiff arteries and other vascular issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Medical College NIH-funded |
| Lab location | 1 site (Valhalla, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $620,514 |
| NIH project number | 5R01HL166546-03 |
| Project ID | NIH-10983801 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with genetic variants of G6PD, particularly those of Mediterranean or African descent, who may be at risk for vascular diseases.
✕Less likely to help
Patients without G6PD variants or those not affected by vascular diseases may not benefit from this research.
What this research studies
This research investigates the role of a newly discovered isoform of glucose-6-phosphate dehydrogenase (G6PD) in regulating the health of vascular smooth muscle cells, which are crucial for maintaining blood vessel function. The study aims to understand how this enzyme influences epigenetic changes and contributes to conditions like arterial stiffness and remodeling, particularly in individuals with certain genetic variants. By examining these mechanisms, the research seeks to uncover potential protective effects against vascular diseases, especially in populations with specific G6PD deficiencies.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating vascular diseases, particularly in individuals with specific genetic backgrounds.
How similar studies have gone: Other research has shown promising results in understanding the role of G6PD in vascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York Medical College
Valhalla, United States Active
Researchers
- Principal investigator: Gupte, Sachin a — New York Medical College
- Study coordinator: Gupte, Sachin a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.