How a mother's gut bacteria affects her child's growth and immunity during undernutrition
The maternal microbiome in childhood growth and immunity during undernutrition
This study is looking at how the bacteria in a mother's gut can affect her child's growth and immune system, especially for kids who are not getting enough nutrition, using mice to learn more about this important connection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11099806 on NIH RePORTER |
What this research studies
This research investigates the role of the maternal microbiome in influencing childhood growth and immune development, particularly in the context of undernutrition. By using a mouse model, the study aims to understand how the gut bacteria of mothers can impact their offspring's health, especially in vulnerable populations. The researchers will analyze the gut microbial composition and its effects on the immune system and growth patterns of the offspring. This approach seeks to identify potential therapeutic targets that could improve health outcomes for children affected by undernutrition.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under the age of 11 who are experiencing stunting or other growth-related issues due to undernutrition.
Not a fit: Patients who are not experiencing undernutrition or growth issues, or those over the age of 11, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that enhance childhood growth and immunity in undernourished populations.
How similar studies have performed: While the specific approach of examining the maternal microbiome in relation to childhood growth during undernutrition is novel, related research has shown promising results in understanding the gut microbiota's role in health.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Cowardin, Carrie Adeline — University of Virginia
- Study coordinator: Cowardin, Carrie Adeline
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.