How a mother's genes guide early embryo development
Maternal regulation of microtubules in egg developmental competency
This research explores how a mother's genetic contributions within the egg guide the very first steps of healthy embryonic development.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11161584 on NIH RePORTER |
What this research studies
This project explores the vital role of factors supplied by the mother within her egg, which are essential for initiating healthy embryonic development right after fertilization. These maternal contributions guide the very first stages of life before the embryo's own genes become active. Researchers are using zebrafish as a model, as their egg development shares many similarities with mammals and is easy to observe. By understanding how these maternal factors are regulated, we hope to learn more about reproductive success and fertility.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but its findings could eventually inform future treatments for individuals facing infertility or early pregnancy challenges.
Not a fit: Patients not experiencing issues with fertility or early embryonic development would not directly benefit from this specific foundational research.
Why it matters
Potential benefit: Understanding these early processes could help explain some causes of infertility or challenges in early embryonic development.
How similar studies have performed: While the specific mechanisms of maternal factor regulation are still being uncovered, the importance of maternal contributions to early development is a well-established biological principle.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Mullins, Mary C. — University of Pennsylvania
- Study coordinator: Mullins, Mary C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.