How a mother's bones influence her baby's adrenal gland growth
Regulation of adrenal development and function by the mother's skeleton
This project explores how a protein from a mother's bones might guide the healthy development and function of her baby's adrenal glands.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11140351 on NIH RePORTER |
What this research studies
Our bodies have adrenal glands that produce important hormones, and this project looks at how they grow and work, especially during early life. We want to understand if a specific protein from a mother's bones, called osteocalcin, is essential for her baby's adrenal glands to develop correctly. We are also trying to figure out if this protein directly helps the adrenal glands grow and make hormones by signaling through a specific receptor. Ultimately, we aim to precisely map out when and how the mother's osteocalcin affects her offspring's adrenal gland development and function.
Who could benefit from this research
Good fit: This foundational research focuses on understanding biological mechanisms, so it does not directly involve patient participation at this stage, but future applications could benefit infants with adrenal gland development issues.
Not a fit: Patients seeking immediate treatment options for existing adrenal conditions may not see direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of adrenal gland development and new ways to address conditions like adrenal insufficiency in infants.
How similar studies have performed: This project explores a novel connection between maternal bone and offspring adrenal development, representing a new area of investigation.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Yadav, Vijay K — Rutgers Biomedical and Health Sciences
- Study coordinator: Yadav, Vijay K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.