How a mother's bones influence her baby's adrenal gland development
Regulation of adrenal development and function by the mother's skeleton
This study is looking at how a protein from a mother’s bones, called osteocalcin, influences the growth and hormone production of her baby’s adrenal glands, using mice to learn more about the connection between a mother’s health and her child’s development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11251435 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called osteocalcin, which comes from the mother's skeleton, in the development and function of the adrenal glands in her offspring. By using mouse models, the study aims to understand how maternal osteocalcin affects adrenal growth and hormone production during critical developmental stages. The researchers will explore the genetic and molecular mechanisms involved, focusing on how osteocalcin signals to the adrenal glands and the timing of its effects. This work could provide insights into the biological connections between maternal health and the endocrine system of the offspring.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women or those planning to become pregnant, particularly those with concerns about bone health.
Not a fit: Patients who are not pregnant or do not have a direct interest in maternal-fetal health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing adrenal dysfunction in children by highlighting the importance of maternal bone health during pregnancy.
How similar studies have performed: While the specific focus on maternal osteocalcin and adrenal development is novel, similar research has shown that maternal health significantly impacts fetal development and endocrine function.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Yadav, Vijay K — Rutgers Biomedical and Health Sciences
- Study coordinator: Yadav, Vijay K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.