How a mom's PCOS might affect adult children's heart and kidney health
Project-002
This work looks at whether being born to a mother with PCOS leads to long-term blood pressure and kidney changes in adult sons and daughters and whether treatments can help.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project ID | NIH-11095905 on NIH RePORTER |
What this research studies
Researchers use a rat model that mimics PCOS during pregnancy to follow adult offspring who were born small. They measure hormones, kidney and blood-vessel signals (like ACE, Ang II, and AT1R), inflammation markers, protein in the urine, and blood pressure. The team compares males and females to find sex-specific effects and tests a drug combination that clears senescent cells to see if it lowers proteinuria and blood pressure. The goal is to link pregnancy hormone exposure to later heart and kidney risk and to identify possible treatments.
Who could benefit from this research
Good fit: Adults born to mothers who had PCOS—especially those born small or who now have high blood pressure or signs of kidney trouble—are the most relevant group.
Not a fit: People whose health issues are unrelated to maternal PCOS or who were not born to a mother with PCOS are unlikely to benefit directly from these findings.
Why it matters
Potential benefit: If successful, this work could point to new ways to prevent or treat high blood pressure and kidney problems in adults born to women with PCOS.
How similar studies have performed: Prior animal studies suggest targeting senescent cells and the renin-angiotensin system can help blood pressure and kidney outcomes, but human testing is limited.
Where this research is happening
Jackson, United States
- University of Mississippi Med Ctr — Jackson, United States (Active)
Researchers
- Principal investigator: Shawky, Noha — University of Mississippi Med Ctr
- Study coordinator: Shawky, Noha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.