How a middle-school prevention program affected lives and costs

Investing in Prevention Infrastructure: Economic Evaluation of the PROSPER System

NIH-funded research Pennsylvania State University, the · NIH-11308662

This project finds out whether a school- and family-based prevention system delivered in middle school led to long-term health and money benefits for the youth who received it.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionPennsylvania State University, the NIH-funded
Lab location1 site (University Park, United States)
Project IDNIH-11308662 on NIH RePORTER

What this research studies

As someone who or whose community took part in a middle-school prevention program, this work looks at how that program affected people’s lives and costs into adulthood. It uses data from over 12,000 youth who took part in the original PROSPER effort and follows their outcomes years later. The team will link those long-term results to economic measures to estimate savings for individuals and communities. They will also examine how local program quality and supports changed how efficiently prevention worked.

Who could benefit from this research

Good fit: Ideal candidates for follow-up are people who participated in the original PROSPER trial as middle-school students or adults from those rural communities.

Not a fit: People who were never part of the original program or who live outside the rural communities studied are unlikely to be directly involved or to receive benefit from this specific project.

Why it matters

Potential benefit: If successful, this could show that investing in early school- and family-based prevention reduces substance misuse later and produces economic savings for individuals and communities.

How similar studies have performed: Earlier PROSPER trials demonstrated reduced substance misuse among participants, but measuring the full long-term economic impact is newer and less established.

Where this research is happening

University Park, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.