How a key protein called desmoplakin works in skin cells
Desmoplakin Assembly and Function in Epidermis
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY · NIH-11074693
This research explores how a protein called desmoplakin helps skin and heart cells stick together, which could lead to new ways to help people with related genetic conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11074693 on ClinicalTrials.gov |
What this research studies
Our bodies rely on a protein called desmoplakin (DP) to help cells in the skin and heart stay connected and strong. When DP doesn't work correctly, it can lead to serious conditions affecting these tissues. We are learning that DP does more than just connect cells; it also helps cells communicate and adapt to their environment. This project uses advanced lab models, including human cell models and models of human diseases, to understand exactly how DP helps cells form strong connections. By understanding these processes, we hope to find new ways to support tissue health.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to help individuals with genetic conditions affecting desmoplakin, which can impact the skin and heart.
Not a fit: Patients whose conditions are not related to desmoplakin or cell adhesion in the skin and heart would likely not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of how skin and heart diseases caused by desmoplakin problems develop, potentially paving the way for new treatments.
How similar studies have performed: This grant builds upon previous findings from the same research group, suggesting a track record of success in this area, while also exploring new aspects of desmoplakin's role.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GREEN, KATHLEEN JANEE — NORTHWESTERN UNIVERSITY
- Study coordinator: GREEN, KATHLEEN JANEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiac Diseases