How a key factor influences gene activation and DNA replication in embryos
Official title: Pioneer factor activity in transcription and DNA replication
Funded at New York University · NIH-11240377 · Data updated 2026-11-12
This study looks at how a protein called Zelda helps fruit fly embryos grow by turning on genes and managing DNA copying right after fertilization, using special imaging techniques to see these important processes in action.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $16,250 |
| NIH project number | 3R35GM148241-03S1 |
| Project ID | NIH-11240377 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the genetic and developmental mechanisms of early embryonic development.
✕Less likely to help
Patients with conditions unrelated to genetic or developmental processes may not receive any benefit from this research.
What this research studies
This research investigates the role of a protein called Zelda in the early development of fruit fly embryos, specifically how it helps activate genes and manage DNA replication. By using advanced microscopy techniques, the researchers aim to understand how Zelda forms structures that facilitate gene expression while ensuring that DNA replication occurs at the right time. This study focuses on the intricate processes that happen shortly after fertilization, which are crucial for proper embryo development.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of developmental processes that may inform treatments for genetic disorders.
How similar studies have gone: Other research has shown success in understanding gene activation mechanisms in developmental biology, making this approach promising.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Rushlow, Christine a — New York University
- Study coordinator: Rushlow, Christine a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.