How a key factor influences gene activation and DNA replication in embryos
Official title: Pioneer factor activity in transcription and DNA replication
Funded at New York University · NIH-10990991 · Data updated 2026-11-12
This study is looking at how a key factor called Zelda helps Drosophila embryos grow properly by activating important genes and managing DNA copying, so scientists can better understand how these processes work together during early development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $352,908 |
| NIH project number | 5R35GM148241-03 |
| Project ID | NIH-10990991 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals interested in the genetic and developmental mechanisms underlying embryonic growth and related conditions.
✕Less likely to help
Patients with established developmental disorders that are not linked to the mechanisms being studied may not benefit from this research.
What this research studies
This research investigates the role of a crucial factor called Zelda in the early development of Drosophila embryos, focusing on how it activates genes and regulates DNA replication. By using advanced microscopy techniques, the researchers aim to understand how Zelda facilitates the binding of other transcription factors and organizes them into functional hubs within the cell nucleus. The study seeks to uncover the timing mechanisms that ensure transcription and DNA replication occur without conflict, which is vital for proper embryonic development.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of developmental processes, potentially informing treatments for developmental disorders.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown success in understanding gene activation and regulation in developmental biology.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Rushlow, Christine a — New York University
- Study coordinator: Rushlow, Christine a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.