How a key enzyme helps the body fight viral infections
Official title: Mechanisms of Enzyme Regulation by Viperin in the Cellular Antiviral Response
Funded at University of Michigan at Ann Arbor · NIH-10841750 · Data updated 2026-11-12
This study is looking at how a special enzyme called viperin helps your body fight off viruses like HIV and hepatitis C, with the goal of finding new ways to improve treatments for viral infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $375,336 |
| NIH project number | 1R35GM153307-01 |
| Project ID | NIH-10841750 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals infected with viruses such as HIV or hepatitis C, or those at risk of such infections.
✕Less likely to help
Patients with viral infections that are not influenced by the mechanisms studied, or those with non-viral related health issues, may not benefit from this research.
What this research studies
This research investigates the role of viperin, an enzyme that is crucial in the body's antiviral response. It aims to understand how viperin regulates various cellular metabolic pathways to limit viral replication and enhance the immune response against infections like HIV and hepatitis C. By studying the biochemical mechanisms involved, the research seeks to identify new strategies for developing effective antiviral therapies. Patients may benefit from insights gained into how their bodies can better combat viral infections.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antiviral treatments for patients with viral infections.
How similar studies have gone: Previous research has shown promising results in understanding the antiviral properties of enzymes like viperin, indicating that this approach has potential for success.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Marsh, E Neil — University of Michigan at Ann Arbor
- Study coordinator: Marsh, E Neil
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.