How a hormone from fat cells affects obesity
Official title: Distinct functions of adipocyte-derived FGF21 in obesity
Funded at University of Washington · NIH-11043365 · Data updated 2026-11-12
This study is looking at how a hormone called FGF21, made by fat cells, affects weight and blood sugar levels in people with obesity, using animal models to find new ways to help with weight loss and improve metabolic health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $485,375 |
| NIH project number | 5R01DK135756-02 |
| Project ID | NIH-11043365 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals struggling with obesity or metabolic syndrome.
✕Less likely to help
Patients who are not overweight or do not have metabolic issues may not benefit from this research.
What this research studies
This research investigates the role of fibroblast growth factor 21 (FGF21), a hormone produced by fat cells, in the context of obesity. It aims to understand how this hormone influences body weight and glucose metabolism, particularly in individuals with obesity. The study will utilize animal models to explore the distinct functions of FGF21 derived from adipose tissue compared to that from the liver, focusing on its effects on energy balance and insulin sensitivity. By examining these mechanisms, the research seeks to identify potential new strategies for weight loss and metabolic health.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for obesity and related metabolic disorders.
How similar studies have gone: Previous research has shown promising results regarding the role of FGF21 in metabolism, but the specific focus on adipocyte-derived FGF21 is relatively novel.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Den Hartigh, Laura Jane — University of Washington
- Study coordinator: Den Hartigh, Laura Jane
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.