How a high fructose diet affects gut health and metabolism
Official title: The effects of a high fructose diet on the gut microbiome and metabolic health: A controlled clinical intervention study
Funded at Icahn School of Medicine at Mount Sinai · NIH-11030720 · Data updated 2026-11-12
This study is looking at how eating a lot of fructose affects your gut health and metabolism, and it's for people interested in understanding the connection between their diet and conditions like insulin resistance and type 2 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 15, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $656,688 |
| NIH project number | 5R01DK137968-02 |
| Project ID | NIH-11030720 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults and children who consume high levels of fructose and may be at risk for metabolic disorders.
✕Less likely to help
Patients who do not consume significant amounts of fructose or have pre-existing conditions that severely limit their dietary intake may not benefit from this research.
What this research studies
This research investigates the impact of a high fructose diet on gut microbiome and metabolic health. Participants will be randomly assigned to consume either a fructose or glucose diet for 12 days, followed by a controlled washout period. The study aims to understand how excess fructose alters gut bacteria and its potential link to conditions like insulin resistance and type 2 diabetes. By analyzing stool samples and metabolic markers, researchers hope to uncover the mechanisms behind these health effects.
Why it matters
Potential benefit: If successful, this research could lead to better dietary recommendations and interventions for improving metabolic health.
How similar studies have gone: Previous research has indicated that dietary changes can significantly impact gut microbiome composition and metabolic health, suggesting potential for success in this approach.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Walker, Ryan — Icahn School of Medicine at Mount Sinai
- Study coordinator: Walker, Ryan
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.