How a high fructose diet affects gut health and metabolism
The effects of a high fructose diet on the gut microbiome and metabolic health: A controlled clinical intervention study
This study is looking at how eating a lot of fructose affects your gut health and metabolism, and it's for people interested in understanding the connection between their diet and conditions like insulin resistance and type 2 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11030720 on NIH RePORTER |
What this research studies
This research investigates the impact of a high fructose diet on gut microbiome and metabolic health. Participants will be randomly assigned to consume either a fructose or glucose diet for 12 days, followed by a controlled washout period. The study aims to understand how excess fructose alters gut bacteria and its potential link to conditions like insulin resistance and type 2 diabetes. By analyzing stool samples and metabolic markers, researchers hope to uncover the mechanisms behind these health effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults and children who consume high levels of fructose and may be at risk for metabolic disorders.
Not a fit: Patients who do not consume significant amounts of fructose or have pre-existing conditions that severely limit their dietary intake may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better dietary recommendations and interventions for improving metabolic health.
How similar studies have performed: Previous research has indicated that dietary changes can significantly impact gut microbiome composition and metabolic health, suggesting potential for success in this approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Walker, Ryan — Icahn School of Medicine at Mount Sinai
- Study coordinator: Walker, Ryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.