How a gut fungus affects healing in intestinal injuries
Official title: Microbe dependent mechanisms that antagonize intestinal injury repair
Funded at Case Western Reserve University · NIH-11086699 · Data updated 2026-11-12
This study is looking at how a specific gut fungus might affect healing in people with Crohn's disease by seeing how it interacts with immune cells, which could help us find better ways to support recovery from intestinal injuries.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $54,538 |
| NIH project number | 5F30DK138707-03 |
| Project ID | NIH-11086699 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with Crohn's disease who experience delayed wound healing in the intestines.
✕Less likely to help
Patients without Crohn's disease or those not experiencing intestinal injuries may not benefit from this research.
What this research studies
This research investigates the role of the gut fungus Debaryomyces hansenii in the healing process of intestinal injuries, particularly in patients with Crohn's disease. It aims to understand how this fungus interacts with immune cells, specifically macrophages, and how it may delay wound healing. The study will utilize both laboratory models and patient-derived samples to explore the mechanisms behind this interaction and the potential for improved healing outcomes. By examining how macrophages respond to this fungus, the research seeks to uncover new insights into the biology of intestinal repair.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for enhancing intestinal healing in patients with Crohn's disease and other inflammatory bowel conditions.
How similar studies have gone: Other research has shown promising results in understanding the role of gut microbiota in intestinal health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Newhall, Kevin Prescott — Case Western Reserve University
- Study coordinator: Newhall, Kevin Prescott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.