How a genetic mutation and ozone exposure affect lung disease progression
Role of Surfactant Protein-C Mutation and Ozone Exposure in the Exacerbation of Pulmonary Fibrosis
This study is looking at how a certain genetic change and exposure to ozone might make pulmonary fibrosis worse, using a special mouse model to help us understand how these factors affect the disease, which could lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10993657 on NIH RePORTER |
What this research studies
This research investigates the impact of a specific genetic mutation in surfactant protein-C and exposure to ozone on the worsening of pulmonary fibrosis, a serious lung disease. By using a novel mouse model that mimics human disease, the study aims to understand how these factors contribute to acute exacerbations of the condition. The research focuses on the role of immune cells, particularly monocytes and macrophages, in the inflammation and progression of pulmonary fibrosis. Patients may benefit from insights gained into the mechanisms of their disease and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with pulmonary fibrosis, particularly those with mutations in the surfactant protein-C gene.
Not a fit: Patients without pulmonary fibrosis or those not exposed to environmental factors like ozone may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of pulmonary fibrosis, potentially enhancing patient outcomes.
How similar studies have performed: Other research has shown success in understanding pulmonary diseases through similar genetic and environmental interaction approaches, making this study a promising continuation of that work.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Venosa, Alessandro — University of Utah
- Study coordinator: Venosa, Alessandro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.