How a fungus and bacteria work together to cause tooth decay in young children
C. albicans interactions with S. mutans modulate cariogenic biofilm formation and virulence
This study is looking at how a fungus and a type of bacteria work together in kids' mouths to cause tooth decay, with the goal of finding new ways to help prevent cavities in young children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11024764 on NIH RePORTER |
What this research studies
This research investigates the interactions between the fungus Candida albicans and the bacteria Streptococcus mutans, which are linked to severe early-childhood caries (S-ECC). The study aims to understand how these microorganisms form structured groups in saliva that enhance their ability to cause tooth decay. By examining the mechanisms of their interaction, including how they promote acid production and biofilm formation, the research seeks to identify potential targets for preventing dental caries in children. The findings could lead to new strategies for managing oral health in young patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are at risk for or suffering from severe early-childhood caries.
Not a fit: Patients who are older than 11 years or do not have issues related to tooth decay may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for tooth decay in young children.
How similar studies have performed: Other studies have shown promising results in understanding microbial interactions in dental health, making this research a continuation of established findings.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Koo, Hyun — University of Pennsylvania
- Study coordinator: Koo, Hyun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.