How a common parasite affects gene expression and DNA changes in the body
DNA methylation, 3D genome organization and gene expression during Trichomonas vaginalis: host interaction
This study is looking at how the Trichomonas vaginalis parasite affects our body's genes and immune system when it infects us, with the hope of finding better ways to treat infections caused by this parasite.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institute/research/biotechnology Fdn NIH-funded |
| Lab location | 1 site (San Martin, Argentina) |
| Project ID | NIH-11041165 on NIH RePORTER |
What this research studies
This research investigates the interaction between the Trichomonas vaginalis parasite and the human host, focusing on how the parasite alters gene expression and DNA methylation patterns. By examining the 3D organization of the genome, the study aims to uncover the mechanisms that regulate these changes during infection. The research utilizes advanced techniques to analyze DNA modifications and their impact on the host's immune response and overall health. Understanding these interactions could lead to better management of infections caused by this parasite.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with Trichomonas vaginalis infections or are at risk of such infections.
Not a fit: Patients who are not infected with Trichomonas vaginalis or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for infections caused by Trichomonas vaginalis and reduce the risk of severe complications such as infertility and increased susceptibility to HIV.
How similar studies have performed: While the specific approach of examining 6mA DNA methylation in Trichomonas vaginalis is novel, similar studies in other pathogens have shown promising results in understanding host-pathogen interactions.
Where this research is happening
San Martin, Argentina
- Institute/research/biotechnology Fdn — San Martin, Argentina (Active)
Researchers
- Principal investigator: De Miguel, Natalia — Institute/research/biotechnology Fdn
- Study coordinator: De Miguel, Natalia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.