How a cell feedback loop protects against cervical cancer
Role of the YAP1-LATS2 negative feedback loop in cervical carcinogenesis
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11300192
Researchers will find out if a natural feedback loop between two cell proteins (YAP1 and LATS2) helps stop HPV from turning cervical cells into cancer in women at risk.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11300192 on ClinicalTrials.gov |
What this research studies
This work looks at how the YAP1-LATS2 feedback loop keeps cervical cells healthy and what happens when that loop is broken. Scientists will use human cervical epithelial cells and lab models to see whether disrupting this loop lets HPV-related changes progress to cancer. The team will search for molecular signs that predict which HPV lesions might become cancerous and test how restoring the loop affects cell behavior. Findings could point to markers or targets that help prevent or treat cervical cancer driven by HPV.
Who could benefit from this research
Good fit: Women with high-risk HPV infection or cervical intraepithelial neoplasia (precancerous cervical lesions) would be the most relevant group to benefit from these findings.
Not a fit: People without HPV-related cervical disease or those with unrelated cancers are unlikely to benefit directly from this grant's findings.
Why it matters
Potential benefit: If successful, this research could identify markers and molecular targets that help prevent HPV infections from progressing to cervical cancer or guide new treatments.
How similar studies have performed: Previous laboratory studies have linked the Hippo/YAP1 pathway to several cancers, but applying the YAP1-LATS2 feedback concept specifically to HPV-driven cervical cancer is relatively new.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, CHENG — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: WANG, CHENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Cause, Cancer Etiology, Cancers