How a brain region helps with learning and memory during changes in attention
Official title: Locus coeruleus regulation of hippocampal network reset during learning
Funded at University of New Mexico Health Scis Ctr · NIH-11109145 · Data updated 2026-11-12
This study looks at how a part of the brain called the locus coeruleus helps another area, the hippocampus, when we learn something new, especially when our attention changes unexpectedly, and it aims to understand how this helps our brains stay flexible and adapt to new experiences.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project start | May 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $677,261 |
| NIH project number | 1R01MH140076-01 |
| Project ID | NIH-11109145 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing attention deficits or cognitive flexibility issues, such as those with ADHD or related conditions.
✕Less likely to help
Patients with stable cognitive function and no attention-related issues may not benefit from this research.
What this research studies
This research investigates how the locus coeruleus, a brain region, influences the hippocampus during learning, particularly when attention shifts due to unexpected changes. By studying the interactions between these areas, the research aims to understand how noradrenergic signaling helps reset neural networks to enhance cognitive flexibility. The approach includes advanced techniques like electrophysiology and optogenetics in awake mice to observe these processes in real-time. This could provide insights into how our brains adapt to new information and experiences.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing learning and memory in individuals with attention-related challenges.
How similar studies have gone: Previous research has shown promising results in understanding the role of noradrenergic signaling in cognitive processes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of New Mexico Health Scis Ctr
Albuquerque, United States Active
Researchers
- Principal investigator: Mckenzie, Samuel Arnold — University of New Mexico Health Scis Ctr
- Study coordinator: Mckenzie, Samuel Arnold
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.