How a brain hormone affects our sense of smell
Centrifugal regulation of olfactory function by melanin-concentrating hormone
This study is looking at how a brain chemical called melanin-concentrating hormone (MCH) affects our sense of smell, especially when we're hungry or tired, to help us understand how these feelings might change how we smell things.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11080960 on NIH RePORTER |
What this research studies
This research investigates how melanin-concentrating hormone (MCH) influences the sense of smell, particularly in relation to physiological states like hunger and sleep. By examining the connections between MCH neurons in the hypothalamus and the olfactory bulb, the study aims to understand how these factors can alter olfactory processing. The research employs molecular and biochemical techniques to measure changes in MCH levels in response to food restriction, providing insights into the mechanisms behind olfactory function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing changes in their sense of smell due to factors like sleep deprivation or dietary changes.
Not a fit: Patients with stable olfactory function and no physiological changes affecting their sense of smell may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing olfactory function, which is crucial for health and quality of life.
How similar studies have performed: While the specific role of MCH in olfactory function is relatively novel, related research has shown that neuropeptides can significantly influence sensory processing.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Alvina, Karina — University of Florida
- Study coordinator: Alvina, Karina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.