How a bacterium modifies host proteins to survive inside cells
Mechanism of atypical ubiquitination and deubiquitination by bacterial effectors
['FUNDING_R01'] · PURDUE UNIVERSITY · NIH-11100470
This study is looking at how the Legionella bacteria change our body's proteins to help them survive and grow, which could help us find new ways to treat infections caused by this germ.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PURDUE UNIVERSITY (nih funded) |
| Locations | 1 site (WEST LAFAYETTE, UNITED STATES) |
| Trial ID | NIH-11100470 on ClinicalTrials.gov |
What this research studies
This research investigates how the bacterium Legionella pneumophila uses unique mechanisms to modify host proteins, which is crucial for its survival and replication within human cells. The study focuses on the SidE family of effectors, particularly SdeA, which employs a novel method of ubiquitination that differs from traditional eukaryotic processes. By understanding these mechanisms, researchers aim to uncover how the bacterium manipulates host cellular functions, including nutrient acquisition and autophagy. This could lead to insights into potential therapeutic targets for treating infections caused by this pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with Legionnaires' disease or are at risk of infection from Legionella pneumophila.
Not a fit: Patients who do not have any history of Legionnaires' disease or related infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating infections caused by Legionella pneumophila.
How similar studies have performed: Other research has shown success in understanding bacterial manipulation of host cellular processes, indicating that this approach has potential for significant findings.
Where this research is happening
WEST LAFAYETTE, UNITED STATES
- PURDUE UNIVERSITY — WEST LAFAYETTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAS, CHITTARANJAN — PURDUE UNIVERSITY
- Study coordinator: DAS, CHITTARANJAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.