How 3D chromosomal structure affects leukemia development
Oncogenic triggers and their influence on 3D chromosomal architecture
This study is looking at how the 3D structure of our DNA might play a role in different types of leukemia, especially T cell and B cell leukemia, to help us understand the genetic changes that could lead to new treatments for patients like you.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11015499 on NIH RePORTER |
What this research studies
This research investigates the role of 3D chromosomal architecture in the development of various types of leukemia, particularly focusing on T cell leukemia and B cell acute lymphoblastic leukemia. By examining how specific DNA elements interact within the nucleus, the study aims to understand the genetic mutations that influence these interactions and their impact on gene expression. The research employs advanced computational tools to analyze these complex 3D structures and their regulatory functions in cancer genomes. Patients may benefit from insights that could lead to new therapeutic strategies targeting these genetic mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with T cell leukemia, B cell acute lymphoblastic leukemia, or related pediatric blood neoplasms.
Not a fit: Patients with non-hematological cancers or those without a diagnosis of the specified leukemias may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for leukemia by targeting the genetic mechanisms that drive the disease.
How similar studies have performed: Previous studies have successfully linked 3D chromosomal architecture to gene regulation in cancer, suggesting that this approach has potential for meaningful advancements in understanding leukemia.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Aifantis, Iannis — New York University School of Medicine
- Study coordinator: Aifantis, Iannis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.