Host-plasmid dynamics in ESBL-Klebsiella pneumoniae spread
Official title: Dissecting the host-plasmid interplay to unravel the spread of ESBL-producing K. pneumoniae
Funded at Hackensack University Medical Center · NIH-11391395 · Data updated 2026-11-12
This grant supports a study of how bacteria carry and share genetic traits that make ESBL-producing Klebsiella pneumoniae hard to treat, with a focus on real patient-derived samples and community infections.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hackensack University Medical Center NIH-funded |
| Lab location | 1 site (Hackensack, United States) |
| Project start | August 13, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $862,153 |
| NIH project number | 5U01AI187297-02 |
| Project ID | NIH-11391395 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with suspected or confirmed ESBL-producing Klebsiella pneumoniae infections, particularly in community and urinary tract infection contexts.
✕Less likely to help
Individuals without ESBL-producing K. pneumoniae or without access to antibiotic-resistance diagnostics may see limited direct benefit.
What this research studies
Researchers will analyze bacterial genomes from ESBL-Kp isolates collected from community patients, using partnerships with diagnostic labs to understand how plasmids spread among strains. The project aims to map how host and plasmid factors contribute to antibiotic resistance and dissemination in the community setting. Findings could inform better diagnostics and targeted strategies to prevent and treat resistant infections in patients.
Why it matters
Potential benefit: Could lead to improved tests and treatment approaches for resistant Klebsiella infections.
How similar studies have gone: Previous work has shown complex plasmid-mediated spread; this study expands understanding to community isolates and plasmid diversity.
Where this research is happening
-
Hackensack University Medical Center
Hackensack, United States Active
Researchers
- Principal investigator: Kreiswirth, Barry Neal — Hackensack University Medical Center
- Study coordinator: Kreiswirth, Barry Neal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.