Hormone therapy for women with HIV going through menopause
Official title: Hormone Therapy for Peri- and Postmenopausal Women with HIV (HoT)
Funded at Columbia University Health Sciences · NIH-10909163 · Data updated 2026-11-12
This study is looking at how hormone therapy can help women living with HIV who are going through menopause, as they often have worse symptoms than those without HIV, and it will check if this treatment can improve things like hot flashes, mood, sleep, and overall well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $677,556 |
| NIH project number | 5R01AG081155-02 |
| Project ID | NIH-10909163 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are peri- and early postmenopausal women diagnosed with HIV who experience significant vasomotor symptoms.
✕Less likely to help
Patients who are not experiencing menopausal symptoms or who are not diagnosed with HIV may not benefit from this research.
What this research studies
This research investigates the effects of hormone therapy on peri- and postmenopausal women living with HIV, who often experience more severe menopausal symptoms compared to women without HIV. The study will involve a randomized, double-blind, placebo-controlled trial where participants will receive either hormone therapy or a placebo. Researchers will assess the impact of hormone therapy on symptoms like hot flashes, as well as its effects on cognitive function, mood, sleep quality, and overall quality of life. Additionally, the study will explore how hormone therapy influences inflammation and health markers related to bone and cardiovascular health.
Why it matters
Potential benefit: If successful, this research could provide effective treatment options for menopausal symptoms and improve overall health outcomes for women living with HIV.
How similar studies have gone: While hormone therapy has been widely studied in the general population, this specific approach for women with HIV is novel and has not been extensively tested.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Yin, Michael T — Columbia University Health Sciences
- Study coordinator: Yin, Michael T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.