Hormone therapy for women with HIV going through menopause
Hormone Therapy for Peri- and Postmenopausal Women with HIV (HoT)
This study is looking at how hormone therapy can help women living with HIV who are going through menopause, as they often have worse symptoms than those without HIV, and it will check if this treatment can improve things like hot flashes, mood, sleep, and overall well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10909163 on NIH RePORTER |
What this research studies
This research investigates the effects of hormone therapy on peri- and postmenopausal women living with HIV, who often experience more severe menopausal symptoms compared to women without HIV. The study will involve a randomized, double-blind, placebo-controlled trial where participants will receive either hormone therapy or a placebo. Researchers will assess the impact of hormone therapy on symptoms like hot flashes, as well as its effects on cognitive function, mood, sleep quality, and overall quality of life. Additionally, the study will explore how hormone therapy influences inflammation and health markers related to bone and cardiovascular health.
Who could benefit from this research
Good fit: Ideal candidates are peri- and early postmenopausal women diagnosed with HIV who experience significant vasomotor symptoms.
Not a fit: Patients who are not experiencing menopausal symptoms or who are not diagnosed with HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide effective treatment options for menopausal symptoms and improve overall health outcomes for women living with HIV.
How similar studies have performed: While hormone therapy has been widely studied in the general population, this specific approach for women with HIV is novel and has not been extensively tested.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Yin, Michael T — Columbia University Health Sciences
- Study coordinator: Yin, Michael T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.