Hormone-free prebiotic muco-adhesive vaginal gel for postmenopausal vaginal atrophy
Official title: Hormone-Free Prebiotic Muco-Adhesive Gels To Treat Vaginal Atrophy in Post-Menopausal Women
Funded at Moremme-Javore LLC · NIH-11324036 · Data updated 2026-11-12
A hormone-free prebiotic sticky vaginal gel designed to ease dryness, irritation, and discomfort in postmenopausal women.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Moremme-Javore LLC NIH-funded |
| Lab location | 1 site (Hoover, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $70,784 |
| NIH project number | 3R43AG084468-02S1 |
| Project ID | NIH-11324036 on NIH RePORTER |
Who could benefit from this research
✓Could help
Postmenopausal women with symptoms of vaginal atrophy—such as dryness, burning, itching, painful intercourse, or recurrent urinary symptoms—who prefer non-hormonal treatments.
✕Less likely to help
Women needing systemic estrogen therapy, those with active pelvic infections, or people with certain estrogen-sensitive cancers may not be eligible or may not benefit from this gel.
What this research studies
This project aims to develop a hormone-free, prebiotic gel that adheres to the vaginal lining to help restore healthy microbes and reduce inflammation that causes vaginal thinning and dryness. The company will formulate a muco-adhesive product and test its stability, muco-adhesion, and effects on vaginal microbes in lab models and preclinical tests. If safety and performance look promising, small early human safety or pilot studies may be conducted to measure symptom relief and tolerability. The goal is a non-hormonal option for women who avoid estrogen-based treatments.
Why it matters
Potential benefit: Could offer a non-hormonal treatment to reduce vaginal dryness, pain with intercourse, and recurrent irritation for postmenopausal women.
How similar studies have gone: Vaginal estrogen is an established effective treatment, while prebiotic muco-adhesive gels are a newer approach with limited clinical evidence so far.
Where this research is happening
-
Moremme-Javore LLC
Hoover, United States Active
Researchers
- Principal investigator: Akande-Dokun, Janet — Moremme-Javore LLC
- Study coordinator: Akande-Dokun, Janet
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.