Hormone changes around menopause and psychosis risk in women
Hormonal Mechanisms of Perimenopausal Risk for Psychosis in Women
['FUNDING_R01'] · MICHIGAN STATE UNIVERSITY · NIH-11262216
This project looks at whether hormone changes during perimenopause lead to more psychotic symptoms in midlife women.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MICHIGAN STATE UNIVERSITY (nih funded) |
| Locations | 1 site (EAST LANSING, UNITED STATES) |
| Trial ID | NIH-11262216 on ClinicalTrials.gov |
What this research studies
You would join a large group of 750 women that includes those before, during, and after menopause and many with higher psychosis risk. For 35 consecutive days you would report daily on psychotic and related symptoms while researchers collect hormone and other behavioral and neuroendocrine measurements. The study combines self-reports, other informant reports, and biological sampling to link day-to-day symptom changes with ovarian hormone fluctuations. The approach aims to isolate the perimenopausal window as a key time when risk may rise.
Who could benefit from this research
Good fit: Women in midlife across premenopause, perimenopause, and postmenopause—especially those with prior psychotic symptoms, family history, or other risk factors—are the best fit.
Not a fit: Younger women far from menopause, men, or people without any risk factors for psychosis are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could identify hormonal timing and targets that lead to better prevention or treatments for psychosis risk in perimenopausal women.
How similar studies have performed: Related studies show links between low ovarian hormones and increased psychotic symptoms during menstrual-cycle and other reproductive events, but a focused, intensive perimenopause study of this scale is novel.
Where this research is happening
EAST LANSING, UNITED STATES
- MICHIGAN STATE UNIVERSITY — EAST LANSING, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KLUMP, KELLY L — MICHIGAN STATE UNIVERSITY
- Study coordinator: KLUMP, KELLY L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.