HIV's impact on brain cell structure and function
HIV promotes dendritic degeneration by altering microtubule-associated protein
This study is looking at how HIV impacts brain cells, especially the parts that help them communicate, to better understand the thinking and memory problems some people with HIV experience, and it aims to find new ways to help treat these issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10618573 on NIH RePORTER |
What this research studies
This research investigates how HIV affects the structure and function of brain cells, particularly focusing on dendrites, which are crucial for neuronal communication. The study aims to uncover the biological mechanisms behind HIV-related cognitive disorders, known as HAND, by examining the role of microtubule-associated protein 2 (MAP2) in dendritic degeneration. By analyzing cerebrospinal fluid and brain samples from individuals living with HIV, the researchers hope to identify new pathways that could lead to effective treatments for these cognitive impairments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV who are experiencing cognitive or mental health challenges.
Not a fit: Patients who are not living with HIV or those who do not exhibit cognitive impairments related to HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating cognitive disorders in people living with HIV.
How similar studies have performed: While there has been some research on HIV's effects on the brain, this specific investigation into the role of MAP2 in dendritic degeneration represents a novel approach.
Where this research is happening
Washington, United States
- Georgetown University — Washington, United States (Active)
Researchers
- Principal investigator: Mocchetti, Italo — Georgetown University
- Study coordinator: Mocchetti, Italo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.