HIV vaccine ingredients and antibody testing core
Immunogen and Antibody Core
This project makes improved HIV vaccine components and lab tests to help vaccines teach people's immune systems to make broader, more protective antibodies.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11248838 on NIH RePORTER |
What this research studies
If you participate, researchers will design and produce advanced HIV envelope proteins (called SOSIP trimers) and fusion-peptide virus-like particles that mimic parts of the virus. They will look at how these ingredients interact with helper T cells and B cells to try to guide antibody responses toward broader protection. The core will also test human blood samples to measure binding, neutralizing, and Fc-effector antibody functions. These materials and results will support linked projects developing vaccine approaches you might be invited to try in future trials.
Who could benefit from this research
Good fit: Ideal participants include people living with HIV or volunteers enrolled in HIV vaccine studies who can provide blood samples for antibody testing.
Not a fit: People needing immediate clinical treatment for active HIV infection or those not eligible for research blood draws are unlikely to receive direct medical benefit from this preclinical vaccine development work.
Why it matters
Potential benefit: If successful, this work could help produce vaccines that trigger broadly neutralizing antibodies able to protect against many HIV strains.
How similar studies have performed: Stabilized Env SOSIP trimers have reliably induced strain-specific neutralizing antibodies in animals and early human work, but methods to consistently produce broadly neutralizing antibodies remain largely unproven.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Moore, Penelope Linda — University of California at Davis
- Study coordinator: Moore, Penelope Linda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.