HIV proteins and their role in liver fibrosis
Official title: Non-ISGylated HIV proteins are sorted to hepatic exosomes to activate liver fibrosi
Funded at University of Nebraska Medical Center · NIH-11005114 · Data updated 2026-11-12
This study is looking at how some proteins from the HIV virus can make liver problems worse, especially for people who drink a lot, and it hopes to find new ways to help those with HIV and liver issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | August 8, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $220,656 |
| NIH project number | 1R21AA031928-01 |
| Project ID | NIH-11005114 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who also have a history of heavy alcohol consumption.
✕Less likely to help
Patients who are HIV-negative or do not have liver-related complications may not benefit from this research.
What this research studies
This research investigates how certain proteins from the HIV virus contribute to liver fibrosis, particularly in individuals who are also heavy drinkers. It focuses on the mechanisms by which these proteins are secreted in small vesicles from liver cells and how they may activate other liver cells that promote fibrosis. By understanding these processes, the research aims to identify specific components that could be targeted for therapeutic intervention. Patients with HIV and liver issues may find this research particularly relevant.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce liver fibrosis in HIV-infected patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of HIV proteins in liver disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Osna, Natalia Aleksandr — University of Nebraska Medical Center
- Study coordinator: Osna, Natalia Aleksandr
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.