HIV, pregnancy diabetes, and tuberculosis risk during pregnancy
Official title: HIV, gestational diabetes and TB in pregnancy
Funded at Weill Medical Coll of Cornell Univ · NIH-11121059 · Data updated 2026-11-12
This project looks at how HIV and gestational diabetes affect a pregnant woman's immune response to tuberculosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $665,122 |
| NIH project number | 5R01AI162235-04 |
| Project ID | NIH-11121059 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant women in their second trimester attending the BJ Government Medical College antenatal clinic, including those living with HIV or at risk for gestational diabetes, are the intended participants.
✕Less likely to help
People who are not pregnant or pregnant women who cannot attend the Pune clinic visits or live outside the recruitment area are unlikely to directly benefit from participation.
What this research studies
As a participant, you would be enrolled in your second trimester at an antenatal clinic in Pune, India and followed through delivery and up to 12 months after birth. Staff will screen for gestational diabetes, record HIV status and treatment, and collect blood and other samples at visits in the third trimester, delivery, 6 weeks, 6 months, and 12 months postpartum. The researchers will compare immune responses to Mycobacterium tuberculosis among women with and without HIV and with and without gestational diabetes to find immune changes that may raise TB risk. The work is done in partnership between BJ Government Medical College (Pune) and Weill Cornell Medicine.
Why it matters
Potential benefit: If successful, the findings could help explain why pregnant women with HIV get TB more often and guide better screening or prevention during and after pregnancy.
How similar studies have gone: Previous studies link HIV and diabetes with higher TB risk outside pregnancy and preliminary data suggest gestational diabetes harms TB immunity, but this combined question in pregnancy is not well studied.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Mathad, Jyoti S — Weill Medical Coll of Cornell Univ
- Study coordinator: Mathad, Jyoti S
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This study is looking at how HIV and gestational diabetes might increase the risk of tuberculosis in pregnant women, and it’s for expectant moms in their second trimester who want to understand more about their health during pregnancy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.