HIV, pregnancy diabetes, and tuberculosis risk during pregnancy
HIV, gestational diabetes and TB in pregnancy
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11121059
This project looks at how HIV and gestational diabetes affect a pregnant woman's immune response to tuberculosis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11121059 on ClinicalTrials.gov |
What this research studies
As a participant, you would be enrolled in your second trimester at an antenatal clinic in Pune, India and followed through delivery and up to 12 months after birth. Staff will screen for gestational diabetes, record HIV status and treatment, and collect blood and other samples at visits in the third trimester, delivery, 6 weeks, 6 months, and 12 months postpartum. The researchers will compare immune responses to Mycobacterium tuberculosis among women with and without HIV and with and without gestational diabetes to find immune changes that may raise TB risk. The work is done in partnership between BJ Government Medical College (Pune) and Weill Cornell Medicine.
Who could benefit from this research
Good fit: Pregnant women in their second trimester attending the BJ Government Medical College antenatal clinic, including those living with HIV or at risk for gestational diabetes, are the intended participants.
Not a fit: People who are not pregnant or pregnant women who cannot attend the Pune clinic visits or live outside the recruitment area are unlikely to directly benefit from participation.
Why it matters
Potential benefit: If successful, the findings could help explain why pregnant women with HIV get TB more often and guide better screening or prevention during and after pregnancy.
How similar studies have performed: Previous studies link HIV and diabetes with higher TB risk outside pregnancy and preliminary data suggest gestational diabetes harms TB immunity, but this combined question in pregnancy is not well studied.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MATHAD, JYOTI S — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: MATHAD, JYOTI S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, Adult-Onset Diabetes Mellitus