HIV envelope shapes that help antibodies kill infected cells
Exploring HIV-1 Env open conformations for therapeutic intervention
This project looks at specific shapes of the HIV outer protein to help antibodies and immune cells better find and kill HIV-infected cells in people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11250416 on NIH RePORTER |
What this research studies
From a patient's perspective, researchers are studying the different shapes of the HIV envelope protein (Env) that sits on virus particles and infected cells. They will compare Env forms, including ones common in the CRF01_AE subtype, map where antibodies bind, and use laboratory immune tests to see which shapes let antibodies trigger infected-cell killing through ADCC. The team uses structural biology and lab-based assays with viruses and antibody samples to pinpoint vulnerable Env conformations. Findings are intended to guide new vaccine or antibody approaches that recruit the immune system to clear infected cells.
Who could benefit from this research
Good fit: People living with HIV who are willing to provide blood samples, especially those with viruses from the CRF01_AE subtype or treated with ART, would be ideal candidates to contribute samples or data.
Not a fit: People without HIV or those expecting an immediate personal cure from participation are unlikely to receive direct clinical benefit from this research.
Why it matters
Potential benefit: If successful, this work could inform vaccines or antibody therapies that boost immune clearance of HIV-infected cells and help move toward functional cures or reduced reliance on lifelong ART.
How similar studies have performed: Previous work, including signals from the RV144 vaccine trial, suggested ADCC-capable antibodies may help protect against HIV, but turning that signal into consistent therapies remains experimental.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Munro, James B — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Munro, James B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.