HIV drug-resistance information hub
HIV Drug Resistance Database
A public online resource gathers and explains HIV drug-resistance data to help people living with HIV, clinicians, and researchers make better treatment and monitoring decisions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11364978 on NIH RePORTER |
What this research studies
This project builds and maintains a public database that collects HIV genetic sequences, documented resistance mutations, and related clinical outcomes from studies around the world. The team standardizes, annotates, and links mutations in key viral targets (reverse transcriptase, protease, integrase, capsid) to treatment responses. The database includes sequence-analysis tools used by laboratories and clinicians and supports population-level surveillance of transmitted and acquired drug resistance. By making data and tools openly available, it aims to guide treatment choices, detect emerging resistance trends, and inform development of better antiretroviral drugs.
Who could benefit from this research
Good fit: People living with HIV—especially those with virological failure, suspected drug-resistant infection, or who can contribute viral sequence or clinical data—are the most relevant candidates to benefit or participate.
Not a fit: People without HIV or those whose care does not involve resistance testing or sequencing are unlikely to see direct benefit from this database.
Why it matters
Potential benefit: If successful, the resource could help clinicians choose more effective antiretroviral regimens, detect resistant virus sooner, and accelerate development of improved HIV therapies.
How similar studies have performed: Similar disease-specific sequence and resistance databases have already helped link viral mutations to drug response and supported clinical and surveillance work, so this continues a proven approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Shafer, Robert William — Stanford University
- Study coordinator: Shafer, Robert William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.